Cellular Interferon Gamma and Granzyme B Responses to Cytomegalovirus-pp65 and Influenza N1 Are Positively Associated in Elderly.
Identifieur interne : 000B92 ( Main/Exploration ); précédent : 000B91; suivant : 000B93Cellular Interferon Gamma and Granzyme B Responses to Cytomegalovirus-pp65 and Influenza N1 Are Positively Associated in Elderly.
Auteurs : Heidi Theeten [Belgique] ; Catharina Mathei [Belgique] ; Kelly Peeters [Belgique] ; Benson Ogunjimi [Belgique] ; Herman Goossens [Belgique] ; Margareta Ieven [Belgique] ; Pierre Van Damme [Belgique] ; Nathalie Cools [Belgique]Source :
- Viral immunology [ 1557-8976 ] ; 2016.
Descripteurs français
- KwdFr :
- Anticorps antiviraux (sang), Antigènes viraux (immunologie), Cytomegalovirus (immunologie), Femelle, Granzymes (immunologie), Grippe humaine (immunologie), Grippe humaine (virologie), Humains, Immunité cellulaire (immunologie), Infections à cytomégalovirus (immunologie), Infections à cytomégalovirus (mortalité), Infections à cytomégalovirus (virologie), Interféron gamma (immunologie), Mâle, Phosphoprotéines (immunologie), Protéines de la matrice virale (immunologie), Protéines virales (immunologie), Sialidase (immunologie), Sous-type H1N1 du virus de la grippe A (immunologie), Sujet âgé, Vaccination, Vaccins antigrippaux (immunologie), Vieillissement (immunologie).
- MESH :
- immunologie : Antigènes viraux, Cytomegalovirus, Granzymes, Grippe humaine, Immunité cellulaire, Infections à cytomégalovirus, Interféron gamma, Phosphoprotéines, Protéines de la matrice virale, Protéines virales, Sialidase, Sous-type H1N1 du virus de la grippe A, Vaccins antigrippaux, Vieillissement.
- mortalité : Infections à cytomégalovirus.
- sang : Anticorps antiviraux.
- virologie : Grippe humaine, Infections à cytomégalovirus.
- Femelle, Humains, Mâle, Sujet âgé, Vaccination.
English descriptors
- KwdEn :
- Aged, Aging (immunology), Antibodies, Viral (blood), Antigens, Viral (immunology), Cytomegalovirus (immunology), Cytomegalovirus Infections (immunology), Cytomegalovirus Infections (mortality), Cytomegalovirus Infections (virology), Female, Granzymes (immunology), Humans, Immunity, Cellular (immunology), Influenza A Virus, H1N1 Subtype (immunology), Influenza Vaccines (immunology), Influenza, Human (immunology), Influenza, Human (virology), Interferon-gamma (immunology), Male, Neuraminidase (immunology), Phosphoproteins (immunology), Vaccination, Viral Matrix Proteins (immunology), Viral Proteins (immunology).
- MESH :
- chemical , blood : Antibodies, Viral.
- immunology : Aging, Antigens, Viral, Cytomegalovirus, Cytomegalovirus Infections, Granzymes, Immunity, Cellular, Influenza A Virus, H1N1 Subtype, Influenza Vaccines, Influenza, Human, Interferon-gamma, Neuraminidase, Phosphoproteins, Viral Matrix Proteins, Viral Proteins.
- mortality : Cytomegalovirus Infections.
- virology : Cytomegalovirus Infections, Influenza, Human.
- Aged, Female, Humans, Male, Vaccination.
Abstract
Morbidity and mortality in the elderly are associated with viral infections, including influenza and cytomegalovirus (CMV). With increasing age, cellular immunity gains importance in protection to influenza, but latent CMV is highly prevalent and associated with immune dysfunction. An insight into the association between immunity against influenza and CMV adds to the understanding of healthy aging. Here we first aimed to measure influenza-specific cellular immunity using granzyme B (GrzB) and interferon-gamma (IFN-γ)-ELISpot. Next, influenza-specific cellular immunity was associated with humoral and cellular CMV-specific immunity in healthy 65+ elderly. Vaccine trial participants gave additional blood samples 3 weeks after receiving a H1N1 containing vaccine. CMV serology was determined and peripheral blood mononuclear cells were stimulated with influenza N1 or CMV pp65-derived peptide pools for 7 days and rechallenged to assess antigen-specific GgrzB and IFN-γ responses using ELISpot assays. Results were compared using chi-square and correlation analysis. Eighty-three individuals (60% men, 65% CMV IgG+, age range 65-78y) participated. We found significant positive associations between IFN-γ and GrzB responses to both influenza and CMV, but also between a positive CMV serostatus and an influenza N1-specific activation marker response (p = 0.013). CMV pp65 responses were detected in CMV IgG+ individuals, but remarkably also in CMV IgG- individuals (27%). In this study, following influenza vaccination, elderly with cellular immunity against CMV were more likely to have cellular immunity against influenza vaccine N1 antigen. These findings stress the need to continue exploring the possible role of CMV in immunosenescence.
DOI: 10.1089/vim.2015.0071
PubMed: 27002465
Affiliations:
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.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>1 Faculty of Medicine and Health Sciences, Center for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, University of Antwerp , Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author><author><name sortKey="Mathei, Catharina" sort="Mathei, Catharina" uniqKey="Mathei C" first="Catharina" last="Mathei">Catharina Mathei</name><affiliation wicri:level="1"><nlm:affiliation>2 Department of Public Health and Primary Care, Katholieke Universiteit Leuven , Leuven, Belgium .</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>2 Department of Public Health and Primary Care, Katholieke Universiteit Leuven , Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Peeters, Kelly" sort="Peeters, Kelly" uniqKey="Peeters K" first="Kelly" last="Peeters">Kelly Peeters</name><affiliation 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Ieven</name><affiliation wicri:level="1"><nlm:affiliation>1 Faculty of Medicine and Health Sciences, Center for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, University of Antwerp , Antwerp, Belgium .</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>1 Faculty of Medicine and Health Sciences, Center for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, University of Antwerp , Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author><author><name sortKey="Van Damme, Pierre" sort="Van Damme, Pierre" uniqKey="Van Damme P" first="Pierre" last="Van Damme">Pierre Van Damme</name><affiliation wicri:level="1"><nlm:affiliation>1 Faculty of Medicine and Health Sciences, Center for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, University of Antwerp , Antwerp, Belgium .</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>1 Faculty of 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when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aging (immunology)</term><term>Antibodies, Viral (blood)</term><term>Antigens, Viral (immunology)</term><term>Cytomegalovirus (immunology)</term><term>Cytomegalovirus Infections (immunology)</term><term>Cytomegalovirus Infections (mortality)</term><term>Cytomegalovirus Infections (virology)</term><term>Female</term><term>Granzymes (immunology)</term><term>Humans</term><term>Immunity, Cellular (immunology)</term><term>Influenza A Virus, H1N1 Subtype (immunology)</term><term>Influenza Vaccines (immunology)</term><term>Influenza, Human (immunology)</term><term>Influenza, Human (virology)</term><term>Interferon-gamma (immunology)</term><term>Male</term><term>Neuraminidase (immunology)</term><term>Phosphoproteins (immunology)</term><term>Vaccination</term><term>Viral Matrix Proteins 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(immunologie)</term><term>Vieillissement (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes viraux</term><term>Cytomegalovirus</term><term>Granzymes</term><term>Grippe humaine</term><term>Immunité cellulaire</term><term>Infections à cytomégalovirus</term><term>Interféron gamma</term><term>Phosphoprotéines</term><term>Protéines de la matrice virale</term><term>Protéines virales</term><term>Sialidase</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Vaccins antigrippaux</term><term>Vieillissement</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Aging</term><term>Antigens, Viral</term><term>Cytomegalovirus</term><term>Cytomegalovirus Infections</term><term>Granzymes</term><term>Immunity, Cellular</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza Vaccines</term><term>Influenza, Human</term><term>Interferon-gamma</term><term>Neuraminidase</term><term>Phosphoproteins</term><term>Viral Matrix Proteins</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Cytomegalovirus Infections</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à cytomégalovirus</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term><term>Infections à cytomégalovirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Cytomegalovirus Infections</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Vaccination</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term><term>Vaccination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Morbidity and mortality in the elderly are associated with viral infections, including influenza and cytomegalovirus (CMV). With increasing age, cellular immunity gains importance in protection to influenza, but latent CMV is highly prevalent and associated with immune dysfunction. An insight into the association between immunity against influenza and CMV adds to the understanding of healthy aging. Here we first aimed to measure influenza-specific cellular immunity using granzyme B (GrzB) and interferon-gamma (IFN-γ)-ELISpot. Next, influenza-specific cellular immunity was associated with humoral and cellular CMV-specific immunity in healthy 65+ elderly. Vaccine trial participants gave additional blood samples 3 weeks after receiving a H1N1 containing vaccine. CMV serology was determined and peripheral blood mononuclear cells were stimulated with influenza N1 or CMV pp65-derived peptide pools for 7 days and rechallenged to assess antigen-specific GgrzB and IFN-γ responses using ELISpot assays. Results were compared using chi-square and correlation analysis. Eighty-three individuals (60% men, 65% CMV IgG+, age range 65-78y) participated. We found significant positive associations between IFN-γ and GrzB responses to both influenza and CMV, but also between a positive CMV serostatus and an influenza N1-specific activation marker response (p = 0.013). CMV pp65 responses were detected in CMV IgG+ individuals, but remarkably also in CMV IgG- individuals (27%). In this study, following influenza vaccination, elderly with cellular immunity against CMV were more likely to have cellular immunity against influenza vaccine N1 antigen. These findings stress the need to continue exploring the possible role of CMV in immunosenescence.</div></front></TEI><affiliations><list><country><li>Belgique</li></country></list><tree><country name="Belgique"><noRegion><name sortKey="Theeten, Heidi" sort="Theeten, Heidi" uniqKey="Theeten H" first="Heidi" last="Theeten">Heidi Theeten</name></noRegion><name sortKey="Cools, Nathalie" sort="Cools, Nathalie" uniqKey="Cools N" first="Nathalie" last="Cools">Nathalie Cools</name><name sortKey="Goossens, Herman" sort="Goossens, Herman" uniqKey="Goossens H" first="Herman" last="Goossens">Herman Goossens</name><name sortKey="Ieven, Margareta" sort="Ieven, Margareta" uniqKey="Ieven M" first="Margareta" last="Ieven">Margareta Ieven</name><name sortKey="Mathei, Catharina" sort="Mathei, Catharina" uniqKey="Mathei C" first="Catharina" last="Mathei">Catharina Mathei</name><name sortKey="Ogunjimi, Benson" sort="Ogunjimi, Benson" uniqKey="Ogunjimi B" first="Benson" last="Ogunjimi">Benson Ogunjimi</name><name sortKey="Peeters, Kelly" sort="Peeters, Kelly" uniqKey="Peeters K" first="Kelly" last="Peeters">Kelly Peeters</name><name sortKey="Van Damme, Pierre" sort="Van Damme, Pierre" uniqKey="Van Damme P" first="Pierre" last="Van Damme">Pierre Van Damme</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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